Breast cancer immunotherapy

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Skip to Content. She is the Cancer. Net Associate Editor for Breast Cancer.

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Chiles Research Institute, Portland, Oregon. Importance: There is tremendous interest in using immunotherapy to treat breast cancer, as evidenced by the more than clinical trials ongoing at the time of this narrative review. The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease.

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This is an exciting time in metastatic breast cancer research. Many new treatments for metastatic breast cancer are under study and treatment is improving. Findings from clinical trials will determine whether or not new treatments will become a part of standard care for metastatic breast cancer.

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Xconomy National —. But until this year, the field had nothing for breast cancer, which kills more women than any other cancer type. That changed in March, when the FDA approved a combination of the immunotherapy atezolizumab Tecentriqmade by Roche, and chemotherapy for a subset of patients with an aggressive form of the disease called triple-negative breast cancer.

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This story previously appeared on STAT. Immunotherapy is the story of the decade in cancer therapy. Yet some cancers, including breast cancer, have shown little response to this new class of medicines, particularly when used alone. We believe advancing our understanding of breast cancer biology and pursuing innovative combination approaches could overcome inherent challenges in breast cancer immunotherapy and potentially advance treatment for subtypes of the disease with limited treatment options.

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The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease. Use of ICB as monotherapy has achieved objective responses in patients with breast cancer, with higher rates seen when administered in earlier lines of therapy. For responding patients, those responses are durable.

Some target a particular part of the cancer cell others use the immune system to kill cancer cells. Targeted cancer drugs are treatments that change the way cells work and help the body to control the growth of cancer. Our immune system works to protect us against diseases, including cancer. It normally picks up faulty cells and destroys them.

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