Please take this quick survey to tell us about what happens after you publish a paper. Breast Cancer Research and Treatment. The use of adjuvant chemotherapy following the primary treatment of breast cancer has led to an increased disease-free survival.
If you're struggling to find what you need, call our Support line on 7 days a week, 8am-8pm. Stem cell and bone marrow transplants are used with high-dose chemotherapy to treat and control some cancers. Get information about what to expect after you've had a transplant of stem cells from a donor.
Cancer researchers have announced that by mid-April they will make public the results of the first four large-scale studies comparing standard treatment for advanced breast cancer to a far more aggressive and controversial procedure involving bone-marrow transplants. But the findings may well be equivocal, researchers caution, even though they had hoped the studies would determine once and for all whether the arduous bone-marrow treatment was worthwhile. In all probability there will be controversy.
March 11,by NCI Staff. Some types of cancer cells are surrounded by a dense layer of connective tissue that acts as a barrier to cancer-killing immune cells. That poses a problem for immunotherapies, treatments that depend on interactions between immune cells and cancer cells. But a new NCI-funded study in mouse models of metastatic breast cancer suggests that plerixafor Mozobil —a drug already used for bone marrow transplants —can thin this protective tissue layer and allow more immune cells to reach the tumors.
Researchers in Israel have discovered that breast tumors can boost their growth by recruiting stromal cells originally formed in the bone marrow. The study, which will be published November 23 in the Journal of Experimental Medicinereveals that the recruitment of bone marrow-derived fibroblasts lowers the odds of surviving breast cancer, but suggests that targeting these cells could be an effective way of treating the disease. Within solid tumors, cancer cells are surrounded by other cell types that, though not cancerous themselves, boost tumor growth and metastasis.
The number of allogeneic and autologous bone marrow transplants continues to grow worldwide. Bone marrow transplantation BMT has become standard therapy for many patients with leukemia, lymphoma, multiple myeloma and testicular cancer. Encouraging results of autologous BMT in treating patients with poor-risk breast cancer have led to this approach being tested in nationwide randomized trials.
It was ultimately determined to be no more effective than normal treatment, and to have significantly higher side effects, including treatment-related death. It also gave rise to one of the most serious cases of research misconduct of the 20th century. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person.
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What every physician needs to know about non-infectious complications after bone marrow transplant: secondary cancer Bone marrow transplant is carried out in order to cure a hematologic malignancy; however, by itself it can cause other cancers. Post-transplant malignancy can occur because of either relapse of primary cancer or emergence of a secondary cancer. These malignancies are summarized below.