Abnormal vaginal bleeding and vagifem

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Vaginal estrogen is a form of estrogen that is delivered by intravaginal administration. Vaginally administered estrogens are thereby exerting their effects mainly in the nearby tissue, with more limited systemic effects compared to orally administered estrogens. Vaginally administered estrogen are usually used to treat some menopausal symptoms that are isolated to the vaginavulva and urethra.

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Multiple studies have been conducted regarding its safety and effectiveness. Serious but less common side effects have been reported; read about other possible side effects in the Prescribing Information the Patient Information begins on Page 8. Here are some things to consider with regard to those studies.

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This study compared the effectiveness and user-friendliness of Vagifem an estradiol vaginal tablet and vaginal estrogen cream in the treatment of atrophic vaginitis. One hundred and sixty postmenopausal women with symptoms of atrophic vaginitis were randomly divided into two groups of treatment with Vagifem or with vaginal estrogen cream for 12 weeks. Patients used the medication daily for the first 2 weeks of the study, and twice weekly.

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Please read this leaflet carefully before you start to use this product. The leaflet does not contain all of the information about the product that you may need to know, so please ask your doctor or pharmacist if you have any questions. Other ingredients are: E, lactose, maize starch, magnesium stearate and polyethylene glycol Vagifem is a vaginal tablet containing a small dose of estradiol an oestrogen.

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US Pharm. A lthough relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. Regardless of the cause, excessive or prolonged bleeding may result in iron deficiency anemia, a condition that may be especially problematic in the elderly.

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The most common symptoms of vaginal atrophy are dryness, irritation, and pain during intercourse. Although menopause is the most common cause, vaginal atrophy can result from anything that lowers estrogen production. That includes chemotherapy, radiation, removal of the ovaries during hysterectomy, and use of anti-estrogenic therapies such as aromatase inhibitors, tamoxifen Nolvadexand drugs like leuprolide Lupron and nafarelin Synarelwhich are used to treat fibroids and endometriosis.

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The use of estrogens is contraindicated in patients with undiagnosed, abnormal vaginal bleeding. The risk may be offset substantially by the addition of a progestin but may not be completely abolished. Prior to initiating estrogen therapy, appropriate diagnostic tests should be performed in patients with abnormal vaginal bleeding to rule out endometrial malignancy.

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Vagifem vaginal tablets or pessaries contain the active ingredient estradiol hemihydrate, which is a naturally occuring form of the main female sex hormone, oestrogen. Womens'' ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, and often affect the delicate lining of the vagina.

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Vagifem Estradiol Vaginal Tablet is an easy-to-use vaginal tablet and is a good alternative to oral estrogen pills and patches. Provera Medroxyprogesterone works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

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Drug information provided by: IBM Micromedex. Estradiol vaginal insert and ring are used to treat changes in and around the vagina such as vaginal dryness, itching, and burning caused by low estrogen levels or menopause. Estradiol vaginal ring is also used to treat moderate to severe hot flashes and other symptoms of menopause or low amounts of estrogen.


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